The relationships between Mycoplasma agassizii, a causative agent of upper respiratory disease (URTD), and desert tortoise (Gopherus agassizii), generally illustrate the complexities of disease dynamics in wild vertebrate populations. In this review, we summarize current understanding of URTD in Mojave desert tortoise populations, we illustrate how inadequate knowledge of tortoise immune systems may obfuscate assessment of disease, and we suggest approaches to future management of URTD in desert tortoise populations. We challenge the view that M. agassizii causes consistent levels of morbidity and/or mortality across the Mojave desert. Instead, URTD may be described more accurately as a context-dependent disease. In addition, new evidence [...]
