The Upper Cretaceous Frontier Formation on the Moxa Arch in the western Green River Basin, Wyoming, has had a varied diagenetic history that was controlled in part by differences in composition of detrital framework grains and in burial history. Petrographic examination of 247 thin sections from 13 cores from the south-plunging arch and adjacent deep basin is the basis for diagenetic investigation of sandstones ranging in depth from 2 km to almost 5 km. Major diagenetic events were (1) mechanical compaction by grain rearrangement and deformation of ductile grains, (2) formation of illite and mixed-layer illite-smectite rims, (3) precipitation of quartz overgrowths, (4) precipitation of calcite cement, (5) generation of secondary porosity [...]