Field studies were conducted for two years at two locations near Pendleton and Moro, OR to evaluate the influence of single sub-surface nitrogen (N) fertilizer application timings and multiple N applications on downy brome and winter wheat growth and yield. N applications in fallow, at planting, during the crop season, and several split N application timings were compared to evaluate downy brome interference in winter wheat. N application rates varied between locations as a function of average annual precipitation and accepted agricultural practice. Pendleton and Moro were considered high and low precipitation sites, respectively. At Pendleton in a year of above average precipitation, N applied at planting, in-crop, or split applications [...]