This is a report of geochemical data from various media collected on Isle Royale, a large island in northeastern Lake Superior. Isle Royale became a national park in 1940 and was designated as a wilderness area in 1976. USGS sampling began in 1996 as part of a larger project on the Midcontinent Rift in the Lake Superior region. Data are given in nine Microsoft Excel spreadsheets. All the data are newly acquired by the USGS.