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Apparent tolerance of turkey vultures (Cathartes aura) to the non-steroidal anti-inflammatory drug diclofenac

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Apparent tolerance of turkey vultures (Cathartes aura) to the non-steroidal anti-inflammatory drug diclofenac; 2008; Article; Journal; Environmental Toxicology and Chemistry; Rattner, B.A.; Whitehead, M.A.; Gasper, G.; Meteyer, C.U.; Link, W.A.; Taggart, M.A.; Meharg, A.A.; Pattee, O. H.; Pain, D.J.

Summary

The nonsteroidal anti-inflammatory drug diclofenac is extremely toxic to Old World Gyps vultures (median lethal dose 0.1?0.2 mg/kg), evoking visceral gout, renal necrosis, and mortality within a few days of exposure. Unintentional secondary poisoning of vultures that fed upon carcasses of diclofenac-treated livestock decimated populations in the Indian subcontinent. Because of the widespread use of diclofenac and other cyclooxygenase-2 inhibiting drugs, a toxicological study was undertaken in turkey vultures (Cathartes aura) as an initial step in examining sensitivity of New World scavenging birds. Two trials were conducted entailing oral gavage of diclofenac at doses ranging from 0.08 to 25 mg/kg body weight. Birds were observed for [...]

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Harvested on Mon Nov 30 04:15:53 MST 2015 from MODS XML Service

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Type Scheme Key
local-index unknown 5224908
local-pk unknown 5224908
series unknown Environmental Toxicology and Chemistry

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journalEnvironmental Toxicology and Chemistry
parts
typevolume
value27
typeissue
value11
languageEnglish
citationTypeArticle

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