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Pharmocokinetics of cephalothin and cephalexin in selected avian species

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Pharmocokinetics of cephalothin and cephalexin in selected avian species; 1981; Article; Journal; American Journal of Veterinary Research; Bush, M.; Locke, D.; Neal, L.A.; Carpenter, J.W.

Summary

Plasma concentrations and the biological half-lives of cephalothin and cephalexin in avian species of a variety of body sizes and metabolic rates were studied. The species chosen were eastern bobwhite quail (Colinus v virginianus), pigeons (Columba livia), hybrid rosybill ducks (Netta sp), greater sandhill cranes (Grus canadensis tabida), and emus (Dromiceius novaehollandiae). In the 1st phase of the study, cephalothin sodium was given IM in a dose of 100 mg/kg of body weight. Plasma concentrations reached peak (av 18 micrograms/ml) at 0.5 hour and were measurable 2.5 to 5.5 hours after drug administration. The biological half-life of cephalothin was 16 to 54 minutes; the half-life varied directly with increased species body weight, [...]

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Type Scheme Key
local-index unknown 5221723
local-pk unknown 5221723
series unknown American Journal of Veterinary Research

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journalAmerican Journal of Veterinary Research
parts
typevolume
value42
typeissue
value6
languageEnglish
citationTypeArticle

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