This article was submitted as a runner up and introduction to JIES 7.3, a special issue on the policy, science and dilemmas of nuclear energy in the 21st century. It provides an overview of some of the key challenges surrounding the so-called ‘nuclear renaissance’. It provides a broad context for the more specific concerns with the social and political aspects of radioactive waste which will be considered in the next issue. What are the likely consequences of a global nuclear power renaissance? This article answers that question by exploring six categories of costs and benefits associated with modern nuclear power plants: capital and production costs, safety and reliability, fuel costs, land degradation, water use, and greenhouse gas [...]