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Natural Calcium Isotopic Composition of Urine as a Marker of Bone Mineral Balance

Dates

Year
2007

Citation

Skulan, Joseph, Bullen, Thomas, Anbar, Ariel D, Puzas, J Edward, Shackelford, Linda, LeBlanc, Adrian, and Smith, Scott M, 2007, Natural Calcium Isotopic Composition of Urine as a Marker of Bone Mineral Balance: Clinical Chemistry, v. 53, iss. 6, p. 1155-1158.

Summary

Background: We investigated whether changes in the natural isotopic composition of calcium in human urine track changes in net bone mineral balance, as predicted by a model of calcium isotopic behavior in vertebrates. If so, isotopic analysis of natural urine or blood calcium could be used to monitor short-term changes in bone mineral balance that cannot be detected with other techniques. Methods: Calcium isotopic compositions are expressed as δ44Ca, or the difference in parts per thousand between the 44Ca/40Ca of a sample and the 44Ca/40Ca of a standard reference material. δ44Ca was measured in urine samples from 10 persons who participated in a study of the effectiveness of countermeasures to bone loss in spaceflight, in which 17 [...]

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  • USGS National Research Program

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Added to ScienceBase on Thu Apr 18 09:20:35 MDT 2013 by processing file <b>Geochemical Reactions Between Water and Mineral Substrates.xml</b> in item <a href="https://www.sciencebase.gov/catalog/item/51118c8ae4b0361176563a13">https://www.sciencebase.gov/catalog/item/51118c8ae4b0361176563a13</a>

Additional Information

Identifiers

Type Scheme Key
DOI http://sciencebase.gov/vocab/identifierScheme 10.1373/clinchem.2006.080143

Citation Extension

journalClinical Chemistry
parts
typePages
value1155-1158
typeVolume
value53
typeIssue
value6
citationTypeJournal Article

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