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Prevalent Glucocorticoid and Androgen Activity in US Water Sources

Dates

Year
2012

Citation

Stavreva, Diana A, George, Anuja A, Klausmeyer, Paul, Varticovski, Lyuba, Sack, Daniel, Voss, Ty C, Schiltz, R Louis, Blazer, Vicki S, Iwanowicz, Luke R, and Hager, Gordon L, 2012, Prevalent Glucocorticoid and Androgen Activity in US Water Sources: Scientific Reports, v. 2.

Summary

Contamination of the environment with endocrine disrupting chemicals (EDCs) is a major health concern. The presence of estrogenic compounds in water and their deleterious effect are well documented. However, detection and monitoring of other classes of EDCs is limited. Here we utilize a high-throughput live cell assay based on sub-cellular relocalization of GFP-tagged glucocorticoid and androgen receptors (GFP-GR and GFP-AR), in combination with gene transcription analysis, to screen for glucocorticoid and androgen activity in water samples. We report previously unrecognized glucocorticoid activity in 27%, and androgen activity in 35% of tested water sources from 14 states in the US. Steroids of both classes impact body development, [...]

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Added to ScienceBase on Tue May 07 14:42:30 MDT 2013 by processing file <b>Fish Health Branch, LSC.xml</b>

Additional Information

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Type Scheme Key
DOI http://sciencebase.gov/vocab/identifierScheme 10.1038/srep00937

Citation Extension

journalScientific Reports
parts
typeVolume
value2
citationTypeJournal Article

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