Vegetative filter strips (VFS) are proposed for protection of receiving water bodies and aquatic organisms from pesticides in runoff, but there is debate regarding the efficiency and filter size requirements. This debate is largely due to the belief that no quantitative methodology exists for predicting runoff buffer efficiency when conducting acute and/or chronic environmental exposure assessments. Previous research has proposed a modeling approach that links the U.S. Environmental Protection Agency’s (EPA’s) PRZM/EXAMS with a well-tested process-based model for VFS (VFSMOD). In this research, we apply the modeling framework to determine (1) the most important input factors for quantifying mass reductions of pesticides by VFS in aquatic [...]