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Genome complexity in the coelacanth is reflected in its adaptive immune system

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Genome complexity in the coelacanth is reflected in its adaptive immune system; 2014; Article; Journal; Journal of Experimental Zoology Part B: Molecular and Developmental Evolution; Saha, Nil Ratan; Ota, Tatsuya; Litman, Gary W.; Hansen, John; Parra, Zuly; Hsu, Ellen; Buonocore, Francesco; Canapa, Adriana; Cheng, Jan-Fang; Amemiya, Chris T.

Summary

We have analyzed the available genome and transcriptome resources from the coelacanth in order to characterize genes involved in adaptive immunity. Two highly distinctive IgW-encoding loci have been identified that exhibit a unique genomic organization, including a multiplicity of tandemly repeated constant region exons. The overall organization of the IgW loci precludes typical heavy chain class switching. A locus encoding IgM could not be identified either computationally or by using several different experimental strategies. Four distinct sets of genes encoding Ig light chains were identified. This includes a variant sigma-type Ig light chain previously identified only in cartilaginous fishes and which is now provisionally denoted [...]

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Harvested on Fri Apr 18 14:58:00 MDT 2014 from MODS XML Service

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Type Scheme Key
local-index unknown 70074870
local-pk unknown 70074870
doi http://www.loc.gov/standards/mods/mods-outline-3-5.html#identifier doi:10.1002/jez.b.22558
series unknown Journal of Experimental Zoology Part B: Molecular and Developmental Evolution

Citation Extension

journalJournal of Experimental Zoology Part B: Molecular and Developmental Evolution
parts
typevolume
value322
typeissue
value6
languageEnglish
citationTypeArticle

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