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Work, T.M. , J. Dagenais, , R. Breeden, A. Schneemann, J. Sung, , B. Hew, G.H. Balazs, and J.M. Berestecky. 2014. Green turtles (Chelonia mydas) Have novel asymmetrical antibodies. Journal of Immunology. Published online before print October 23, 2015, doi: 10.4049/jimmunol.1501332

Summary

Igs in vertebrates comprise equally sized H and L chains, with exceptions such as H chain–only Abs in camels or natural Ag receptors in sharks. In Reptilia, Igs are known as IgYs. Using immunoassays with isotype-specific mAbs, in this study we show that green turtles (Chelonia mydas) have a 5.7S 120-kDa IgY comprising two equally sized H/L chains with truncated Fc and a 7S 200-kDa IgY comprised of two differently sized H chains bound to L chains and apparently often noncovalently associated with an antigenically related 90-kDa moiety. Both the 200- and 90-kDa 7S molecules are made in response to specific Ag, although the 90-kDa molecule appears more prominent after chronic Ag stimulation. Despite no molecular evidence of a hinge, electron [...]

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Harvested on Mon Nov 30 04:16:31 MST 2015 from MODS XML Service

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Type Scheme Key
local-index unknown 70159480
local-pk unknown 70159480
doi http://www.loc.gov/standards/mods/mods-outline-3-5.html#identifier doi:10.4049/jimmunol.1501332
series unknown Journal of Immunology

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journalJournal of Immunology
parts
typevolume
value195
typeissue
value11
languageEnglish
citationTypeArticle

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