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Evaluation of the protective immunogencity of the N, P, M, NV and G proteins of infectious hematopoietic necrosis virus in rainbow trout <i>Oncorhynchus mykiss</i> using DNA vaccines

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S. Corbeil, S.E. LaPatra, E.D. Anderson, J. Jones, B. Vincent, Ya Li Hsu, and G. Kurath, 1999, Evaluation of the protective immunogencity of the N, P, M, NV and G proteins of infectious hematopoietic necrosis virus in rainbow trout <i>Oncorhynchus mykiss</i> using DNA vaccines: Diseases of Aquatic Organisms, v. 39, iss. 1.

Summary

The protective immunogenicity of the nucleoprotein (N), phosphoprotein (P), matrix protein (M), non-virion protein (NV) and glycoprotein (G) of the rhabdovirus infectious hematopoietic necrosis virus (IHNV) was assessed in rainbow trout using DNA vaccine technology. DNA vaccines were produced by amplifying and cloning the viral genes in the plasmid pCDNA 3.1. The protective immunity elicited by each vaccine was evaluated through survival of immunized fry after challenge with live virus. Neutralizing antibody titers were also determined in vaccinated rainbow troutOncorhynchus mykiss fry (mean weight 2 g) and 150 g sockeye salmon Oncorhynchus nerka. The serum from the 150 g fish was also used in passive immunization studies with naïve [...]

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Harvested on Sun Jan 31 04:18:18 MST 2016 from MODS XML Service

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Type Scheme Key
local-index unknown 70162381
local-pk unknown 70162381
doi http://www.loc.gov/standards/mods/mods-outline-3-5.html#identifier doi:10.3354/dao039029
series unknown Diseases of Aquatic Organisms

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journalDiseases of Aquatic Organisms
parts
typevolume
value39
typeissue
value1
languageEnglish
citationTypeArticle

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