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Antigenic and functional characterization of p57 produced by <i>Renibacterium salmoninarum</i>

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G. Weins, M.S. Chien, J.R. Winton, and S.L. Kaatari, 1999, Antigenic and functional characterization of p57 produced by <i>Renibacterium salmoninarum</i>: Diseases of Aquatic Organisms, v. 37, iss. 1.

Summary

Renibacterium salmoninarum, the causative agent of bacterial kidney disease, produces large quantities of a 57-58 kDa protein (p57) during growth in broth culture and during infection of salmonid fish. Biological activities of secreted p57 include agglutination of salrnonid leucocytes and rabbit erythrocytes. We define the location of epitopes on p57 recognized by agglutination-blocking monoclonal antibodies (MAbs) 4Cl1, 4H8 and 4D3, and demonstrate that the majority of secreted p57 is a nlonomer that retains salrnonid leucocyte agglutinat~ng activity. The 3 MAbs bound a recombinant, amino-terminal fragment of p57 (211 aa) but not a carboxy-terminal fragment (315 aa) demonstrating that the neutralizing epitopes are located within the [...]

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Harvested on Sun Jan 31 04:16:09 MST 2016 from MODS XML Service

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Type Scheme Key
local-index unknown 70162433
local-pk unknown 70162433
series unknown Diseases of Aquatic Organisms

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journalDiseases of Aquatic Organisms
parts
typevolume
value37
typeissue
value1
languageEnglish
citationTypeArticle

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