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Immunogenicity and efficacy of three recombinant subunit Pasteurella multocida toxin vaccines against progressive atrophic rhinitis in pigs

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Chih-Ming Liao, Chienjin Huang, Shih-Ling Hsuan, Zeng-Weng Chen, Wei-Cheng Lee, Cheng-I Liu, James R. Winton, and Maw-Sheng Chien, 2006, Immunogenicity and efficacy of three recombinant subunit Pasteurella multocida toxin vaccines against progressive atrophic rhinitis in pigs: Vaccine, v. 24, iss. 1.

Summary

Three short fragments of recombinant subunit Pasteurella multocida toxin (rsPMT) were constructed for evaluation as candidate vaccines against progressive atrophic rhinitis (PAR) of swine. PMT-specific antibody secreting cells and evidence of cellular immunity were detected in rsPMT-immunized pigs following authentic PMT challenge or homologous antigen booster. Piglets immunized with rsPMT fragments containing either the N-terminal or the C-terminal portions of PMT developed high titers of neutralizing antibodies. Pregnant sows immunized with rsPMT had higher levels of maternal antibodies in their colostrum than did those immunized with a conventional PAR-toxoid vaccine. Offspring from rsPMT vaccinated sows had better survival after [...]

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Harvested on Tue May 31 04:21:16 MDT 2016 from MODS XML Service

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Type Scheme Key
local-index unknown 70171134
local-pk unknown 70171134
doi http://www.loc.gov/standards/mods/mods-outline-3-5.html#identifier doi:10.1016/j.vaccine.2005.07.079
series unknown Vaccine

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journalVaccine
parts
typevolume
value24
typeissue
value1
languageEnglish
citationTypeArticle

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