Abstract (from https://www.sciencedirect.com/science/article/pii/S2405880717300924): Water managers are increasingly interested in better understanding and planning for projected resource impacts from climate change. In this management-guided study, we use a very large suite of synthetic climate scenarios in a statistical modeling framework to simultaneously evaluate how (1) average temperature and precipitation changes, (2) initial basin conditions, and (3) temporal characteristics of the input climate data influence water-year flow in the Upper Colorado River. The results here suggest that existing studies may underestimate the degree of uncertainty in future streamflow, particularly under moderate temperature and precipitation changes. [...]