Wetland hydroperiod, the length of time water is available in wetlands, is sensitive to changes in precipitation, temperature and timing due to climate variation. Truncated hydroperiod has major implications for wetland-dependent species (e.g., waterfowl, amphibians) and human water allocation (PPP LCC Need 1). To characterize wetland hydroperiod in the Plains and Prairie Pothole Region, we first identify location and hydroperiod of wetlands using field-based and remotely sensed training data (RapidEye, Landsat). We define hydroperiod as wetland ephemerality, where ephemerality represents the persistence of a wetland across the growing season. We then link hydroperiod to climatic variation by relating climate time-series data to wetland ephemerality typified by the proportion of time that a location was classified as a wetland using a specified probability threshold (PPP LCC Need 1). Finally, we predict hydroperiod under a range of climatic conditions representing potential changes to temperature, precipitation, and timing.