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The Florida manatee (Trichechus manatus latirostris) T cell receptor loci exhibit V subgroup synteny and chain-specific evolution

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Breaux, B., Hunter, M.E., Cruz-Schneider, M.P., Seno, L., Bonde, R.K., and Criscitiello, M.F., 2018, The Florida manatee (Trichechus manatus latirostris) T cell receptor loci exhibit V segment locus synteny and chain-specific evolution: Developmental and Comparative Immunology, v. 85, p. 71-85, https://doi.org/10.1016/j.dci.2018.04.007.

Summary

The Florida manatee (Trichechus manatus latirostris) has limited diversity in the immunoglobulin heavy chain. We therefore investigated the antigen receptor loci of the other arm of the adaptive immune system: the T cell receptor. Manatees are the first species from Afrotheria, a basal eutherian superorder, to have an in-depth characterization of all T cell receptor loci. By annotating the genome and expressed transcripts, we found that each chain has distinct features that correlates to their individual functions. The genomic organization also plays a role in modulating sequence conservation between species. There were extensive V subgroup synteny blocks in the TRA and TRB loci between T. m. latirostrisand human. Increased genomic [...]

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Type Scheme Key
local-index unknown 70196617
local-pk unknown 70196617
doi http://www.loc.gov/standards/mods/mods-outline-3-5.html#identifier doi:10.1016/j.dci.2018.04.007
series unknown Developmental and Comparative Immunology

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citationTypeArticle
journalDevelopmental and Comparative Immunology
languageEnglish
parts
typevolume
value85

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