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Virally-vectored vaccine candidates against white-nose syndrome induce anti-fungal immune response in little brown bats (Myotis lucifugus)

Dates

Publication Date
Start Date
2015-11-01
End Date
2018-05-01

Citation

Rocke, T.E., Kingstad-Bakke, B., Wüthrich, M., Stading, B., Abbott, R.C., Isidoro Ayza, M., Dobson, H.E., dos Santos Dias, L., Galles, K., Lankton, J.S., Falendysz, E.A., Lorch, J.M., Fites, J.S., Lopera-Madrid, J., White, J.P., Klein. B., and Osorio, J.E., 2019, Virally-vectored vaccine candidates against white-nose syndrome induce anti-fungal immune response in little brown bats (Myotis lucifugus): U.S. Geological Survey data release, https://doi.org/10.5066/P923NSSG.

Summary

White-nose syndrome (WNS) caused by the fungus, Pseudogymnoascus destructans (Pd) has killed millions of North American insect-eating bats. Currently, methods to prevent the disease are limited. We conducted two trials to assess potential WNS vaccine candidates in wild-caught Myotis lucifugus. In a pilot study, we immunized bats with one of four vaccine treatments or PBS as a control and challenged them with Pd upon transfer into hibernation chambers. Bats in one vaccine-treated group, that received raccoon poxviruses (RCN) expressing Pd calnexin (CAL) and serine protease (SP), developed WNS at a lower rate (1/10) than other treatments combined (14/23), although samples sizes were small. The results of a second similar trial provided [...]

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Attached Files

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2015-16 pilot study.csv 1.81 KB
2017-18 vaccine-challenge study.csv 483.82 KB
WNS vaccine metadata.xml
Original FGDC Metadata

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49.21 KB

Purpose

The dataset was collected to determine if vaccination could be a useful approach for managing white nose syndrome in bats.

Communities

  • National Wildlife Health Center
  • USGS Data Release Products

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Additional Information

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Type Scheme Key
DOI https://www.sciencebase.gov/vocab/category/item/identifier doi:10.5066/P923NSSG

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