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  4. Virally-vectored vaccine candidates against white-nose syndrome induce anti-fungal immune response in little brown bats (Myotis lucifugus)

Virally-vectored vaccine candidates against white-nose syndrome induce anti-fungal immune response in little brown bats (Myotis lucifugus)

Dates

Publication Date
Start Date
2015-11-01
End Date
2018-05-01

Citation

Rocke, T.E., Kingstad-Bakke, B., Wüthrich, M., Stading, B., Abbott, R.C., Isidoro Ayza, M., Dobson, H.E., dos Santos Dias, L., Galles, K., Lankton, J.S., Falendysz, E.A., Lorch, J.M., Fites, J.S., Lopera-Madrid, J., White, J.P., Klein. B., and Osorio, J.E., 2019, Virally-vectored vaccine candidates against white-nose syndrome induce anti-fungal immune response in little brown bats (Myotis lucifugus): U.S. Geological Survey data release, https://doi.org/10.5066/P923NSSG.

Summary

White-nose syndrome (WNS) caused by the fungus, Pseudogymnoascus destructans (Pd) has killed millions of North American insect-eating bats. Currently, methods to prevent the disease are limited. We conducted two trials to assess potential WNS vaccine candidates in wild-caught Myotis lucifugus. In a pilot study, we immunized bats with one of four vaccine treatments or PBS as a control and challenged them with Pd upon transfer into hibernation chambers. Bats in one vaccine-treated group, that received raccoon poxviruses (RCN) expressing Pd calnexin (CAL) and serine protease (SP), developed WNS at a lower rate (1/10) than other treatments combined (14/23), although samples sizes were small. The results of a second similar trial provided [...]

Contacts

Point of Contact :
Tonie E Rocke
Publisher :
U.S. Geological Survey
Originator :
Tonie E. Rocke, Brock Kingstad-Bakke, Marcel Wüthrich, Ben Stading, Rachel C. Abbott, Marcos Isidoro Ayza, Hannah E. Dobson, Lucas dos Santos Dias, Kevin Galles, Julia S. Lankton, Elizabeth A. Falendysz, Jeffrey M. Lorch, J. Scott Fites, Jaime Lopera-Madrid, J. Paul White, Bruce Klein, Jorge E. Osorio
Metadata Contact :
Tonie E Rocke
Distributor :
U.S. Geological Survey - ScienceBase
SDC Data Owner :
National Wildlife Health Center
USGS Mission Area :
Ecosystems

Attached Files

Click on title to download individual files attached to this item.

WNS vaccine metadata.xml
Original FGDC Metadata
View 		51.79 KB application/fgdc+xml
2015-16 pilot study.csv 1.81 KB text/csv
2017-18 vaccine-challenge study.csv 483.82 KB text/csv

Purpose

The dataset was collected to determine if vaccination could be a useful approach for managing white nose syndrome in bats.

Communities

  • National Wildlife Health Center
  • USGS Data Release Products

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Additional Information

Identifiers

Type Scheme Key
DOI https://www.sciencebase.gov/vocab/category/item/identifier doi:10.5066/P923NSSG

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