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Disruption of Francisella noatunensis orientalis pdpA gene results in virulence attenuation and protection in zebrafish

Dates

First Processing Date
2020-11-16
Last Processing Date
2021-11-23
Publication Date

Citation

Hansen, J.D., and Bellah, J.P., 2021, Disruption of Francisella noatunensis orientalis pdpA gene results in virulence attenuation and protection in zebrafish: U.S. Geological Survey data release, https://doi.org/10.5066/P9ZS5IWF.

Summary

Several Francisella spp. including F. noatunensis are regarded as important emerging pathogens of wild and farmed fish. However, very few studies have investigated the virulence factors that allow these bacterial species to be pathogenic in fish. The Francisella Pathogenicity Island (FPI) is a well-described, gene-dense region encoding major virulence factors for the genus Francisella. PdpA is a member of the pathogenicity determining protein genes encoded by the FPI that are implicated in the ability of the mammalian pathogen, F. tularensis, to escape and replicate in infected host cells. Using a sacB suicide approach, we generated pdpA knockouts to address the role of PdpA as a virulence factor for F. noatunensis. Since polarity [...]

Contacts

Point of Contact :
John P Bellah
Originator :
John D Hansen, John P Bellah
Metadata Contact :
John P Bellah
Publisher :
U.S. Geological Survey
Distributor :
U.S. Geological Survey - ScienceBase
USGS Mission Area :
Ecosystems
SDC Data Owner :
Western Fisheries Research Center

Attached Files

Click on title to download individual files attached to this item.

Francisella Study CT Values.csv
“CT values from qPCR.”
21.23 KB text/csv

Purpose

Data was collected to assess the role of PdpA as a virulence factor for F. noatunensis. An appropriate use of the data can be any research investigating the Francisela Pathogenicity Island virulence genes.

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  • USGS Data Release Products

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Type Scheme Key
DOI https://www.sciencebase.gov/vocab/category/item/identifier doi:10.5066/P9ZS5IWF

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