Skip to main content
  1. ScienceBase Catalog
  2. National Wildlife Health Center
  3. NWHC_Data
  4. In vitro expression, immunogenicity, and efficacy data from recombinant raccoon poxvirus-vectored rabies vaccine candidates tested in mice

In vitro expression, immunogenicity, and efficacy data from recombinant raccoon poxvirus-vectored rabies vaccine candidates tested in mice

Dates

Publication Date
Start Date
2020-10-01
End Date
2021-08-01

Citation

Malavé, C.M., Lopera-Madrid, J., Medina-Magües, L.G., Rocke, T.E., and Osorio, J.E., 2021, In vitro expression, immunogenicity, and efficacy data from recombinant raccoon poxvirus-vectored rabies vaccine candidates tested in mice: U.S. Geological Survey data release, https://doi.org/10.5066/P9IERY9D.

Summary

This work is part of an experimental trial to develop and assess novel recombinant raccoonpox virus (RCN) rabies vaccines in the mouse model, for potential use in bats. Briefly, our research group previously developed a recombinant RCN vaccine candidate expressing a mosaic glycoprotein (MoG) gene that protected mice and big brown bats when challenged with rabies virus (RABV). We developed two new recombinant RCN candidates expressing MoG (RCN-tPA-MoG and RCN-SS-TD-MoG) with the aim of improving RCN-MoG. We assessed and compared in vitro expression, in vivo immunogenicity, and protective efficacy in vaccinated mice challenged intracerebrally with RABV. In this data set, we share results of immunofluorescence assay quantification, recombinant [...]

Contacts

Point of Contact :
Carly M Malave
Originator :
Carly M Malave, Jaime Lopera-Madrid, Lex G Medina-Magües, Tonie E Rocke, Jorge E Osorio
Metadata Contact :
Carly M Malave
Publisher :
U.S. Geological Survey
Distributor :
U.S. Geological Survey - ScienceBase
SDC Data Owner :
National Wildlife Health Center
USGS Mission Area :
Ecosystems

Attached Files

Click on title to download individual files attached to this item.

Malave_metadata.xml
Original FGDC Metadata
View 		40.77 KB application/fgdc+xml
Figure 3. Virus growth curve.csv 190 Bytes text/csv
Figure 4. Mouse immunogenecity.csv 1.2 KB text/csv
Figure 5A. Mouse weight change.csv 3.15 KB text/csv
Figure 5B. Mouse weight change.csv 6.22 KB text/csv
Figure 6. Mouse survival.csv 606 Bytes text/csv
Table 1. IF quantification.csv 101 Bytes text/csv

Purpose

These data were collected to compare potential rabies vaccine candidates by testing in cell culture and the mouse model. They can be used to as evidence for continued testing, ideally in the target species (i.e., bats).

Communities

  • National Wildlife Health Center

Tags

Provenance

Additional Information

Identifiers

Type Scheme Key
DOI https://www.sciencebase.gov/vocab/category/item/identifier doi:10.5066/P9IERY9D

Item Actions

View Item as ...

JSON ATOM ISO XML

Save Item as ...

JSON FGDC MODS XML ISO XML

View Item...

Metrics