Chemical-Gene and Chemical-Pathway Interactions Predicted for Chemicals Detected in the USGS-USEPA National Streams Pilot Study Based on Effects Data in the Comparative Toxicogenomics Database (CTD)

Publication Date

2019-07-17

Start Date

2012

End Date

2014

Romanok, K.M., Bradley, P.M., and Berninger, J.P., 2019, Chemical-Gene and Chemical-Pathway Interactions Predicted for Chemicals Detected in the USGS-USEPA National Streams Pilot Study Based on Effects Data in the Comparative Toxicogenomics Database (CTD): U.S. Geological Survey data release, https://doi.org/10.5066/P9A6C39B.

Type: Citation

The U.S. Geological Survey (USGS) and the U.S. Environmental Protection Agency (EPA) assessed 719 unique organic analytes in surface water split samples from 38 United States (US) stream sites representing a national gradient in watershed urban/agricultural development. To complement the chemical analysis of these water samples, organic extracts of the samples were evaluated for in vitro estrogen (ER), androgen (AR), and glucocorticoid (GR) activity and for mutagenicity in the Salmonella (Ames) assay. The predictive utility of knowledgebase-leveraging of comprehensive environmental-contaminant-exposure datasets was assessed using exposure-effects relations identified in the Comparative Toxicogenomincs Database (CTD) to computationally predict chemical-gene/protein associations and analogous chemical-pathway associations for direct comparison with observed ER-, AR-, and GR-activity and mutagenicity results for corresponding split water samples.

• USGS Data Release Products