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Sediment samples and samples for water-toxicity testing were collected during 2014 from several streams in San Antonio, Texas known locally as the Westside creeks (Alazán, Apache, Martínez, and San Pedro Creeks) and from the San Antonio River. Samples were collected once during base-flow and again after periods of storm-water runoff (post-storm conditions) to determine baseline sediment- and water-quality conditions. Streambed-sediment samples were analyzed for selected constituents, including trace elements and organic contaminants such as pesticides, polychlorinated biphenyls (PCBs), brominated flame retardants, and polycyclic aromatic hydrocarbons (PAHs).
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A number of brominated flame retardants (BFRs) have been reported to interfere with the thyroid signaling pathway and cause oxidative stress in birds, yet the underlying shifts in gene expression associated with these effects remain poorly understood. In this study, we measured hepatic transcriptional responses of 31 genes in American kestrel hatchlings following in ovo exposure to one of three high-volume alternative BFRs: 1,2-bis(2,4,6-tribromophenoxy) ethane (BTPBE), bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (TBPH), or 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EHTBB). Hatchling kestrels exhibited shifts in the expression of genes related to oxidative stress (CYP, GSTA, SOD, GPx), thyroid hormone metabolism...
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Observations of test subjects and hatching data - Body weight, organ/tissue weights Biomarker data (oxidative stress indicators, oxidative DNA damage, thyroid hormones, histological findings) in various tissues Chemical residues in tissues


    map background search result map search result map Sediment-quality and water-toxicity data from 10 sites on the Westside Creeks and San Antonio River, San Antonio, Texas, 2014 Biomarker responses in American kestrels exposed in ovo to EHTBB and TBPH Hepatic gene expression transcript counts in liver samples of American kestrels Biomarker responses in American kestrels exposed in ovo to EHTBB and TBPH Sediment-quality and water-toxicity data from 10 sites on the Westside Creeks and San Antonio River, San Antonio, Texas, 2014 Hepatic gene expression transcript counts in liver samples of American kestrels