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This dataset consists of measurements of the digestive gland in the freshwater snail Lymnaea stagnalis orally exposed to uranium. The objective of the study was to assess the morphological effects of uranium on the snail digestive gland by light microscopy. Laboratory-cultured L stagnalis were exposed to either synthetic or natural solid phases of uranium and a subset (6 controls and 6 exposed) were euthanized and fixed in 10% neutral buffered formalin for histopathological assessment. Slides were processed and stained with hematoxalin and eosin as per standard procedure (Luna 1968). The size of each sample, the length and width of digestive gland tubules (5 random glands per sample) and height of digestive cells...
This dataset describes histopathological changes in liver, kidney, gonad, and spleen of zebra finches exposed to 15mg/kg, 30mg/kg or 60mg/kg clothianidin (CTD) in water or on millet seed. The goal of the project is to develop a subacute neonicotinoid toxicity model using zebra finches as a model passerine. We have completed two acute toxicity trials using CTD insecticide. Based on these studies, we estimate the no observable effect level (NOAEL) and the lowest observable effect level (LOAEL) for CTD in zebra finches to be 15 and 30 mg/kg body weight, respectively, and the concentration producing a toxic effect in 50% of treated birds (EC50) to be approximately 150 mg/kg. We next exposed birds for 7 days to CTD in...
This dataset describes histopathological changes in liver, kidney, heart, skeletal muscle and intestine of captive American kestrels sequentially exposed to first and second generation anticoagulant rodenticides (FGAR and SGAR). The goal of the study was to determine the toxicity of sequential exposure to anticoagulant rodenticides (ARs) by evaluating FGAR-FGAR exposure (7 day chlorophacinone exposure, 7 day recovery, than re-exposure) and SGAR-FGAR exposure (7 day brodifacoum, 7 day recovery, than 7 day exposure to chlorophacinone). Birds were necropsied and examined grossly for hemorrhages or anemia, and liver, kidney, heart, skeletal muscle, and intestine was collected for histopathological evaluation. Tissues...
White-nose syndrome (WNS) caused by the fungus, Pseudogymnoascus destructans (Pd) has killed millions of North American insect-eating bats. Currently, methods to prevent the disease are limited. We conducted two trials to assess potential WNS vaccine candidates in wild-caught Myotis lucifugus. In a pilot study, we immunized bats with one of four vaccine treatments or PBS as a control and challenged them with Pd upon transfer into hibernation chambers. Bats in one vaccine-treated group, that received raccoon poxviruses (RCN) expressing Pd calnexin (CAL) and serine protease (SP), developed WNS at a lower rate (1/10) than other treatments combined (14/23), although samples sizes were small. The results of a second...