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This dataset describes histopathological changes in liver, kidney, heart, skeletal muscle and intestine of captive American kestrels sequentially exposed to first and second generation anticoagulant rodenticides (FGAR and SGAR). The goal of the study was to determine the toxicity of sequential exposure to anticoagulant rodenticides (ARs) by evaluating FGAR-FGAR exposure (7 day chlorophacinone exposure, 7 day recovery, than re-exposure) and SGAR-FGAR exposure (7 day brodifacoum, 7 day recovery, than 7 day exposure to chlorophacinone). Birds were necropsied and examined grossly for hemorrhages or anemia, and liver, kidney, heart, skeletal muscle, and intestine was collected for histopathological evaluation. Tissues...