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Prolonged use of broad-spectrum antibiotics has led to the emergence of drug-resistant pathogens, both in medicine and in agriculture. New threats such as biological warfare have increased the need for novel and efficacious antimicrobial agents. Natural habitats not previously examined as sources of novel antibiotic-producing microorganisms still exist. One such habitat is the rhizosphere of desert shrubs. Here, we show that one desert shrub habitat, the rhizosphere of desert big sagebrush (Artemisia tridentata) is a source of actinomycetes capable of producing an extensive array of antifungal metabolites. Culturable microbial populations from both the sagebrush rhizosphere and nearby bulk soils from three different...
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Bacterial kidney disease (BKD) caused by Renibacterium salmoninarum (Rs) occurs nearly worldwide where wild or cultured salmonid fishes are present. Control of BKD is confounded by its two modes of transmission, horizontal (fish-to-fish) and vertical (from female parent to progeny via the eggs). A highly successful BKD control strategy employed in Pacific Northwest hatcheries culturing spring Chinook salmon (Oncorhynchus tshawytscha) includes: (1) injecting pre-spawning adults with a macrolide antibiotic to improve survival and reduce Rs infection levels, (2) broodstock culling of highly infected females and (3) improved fish husbandry. However, the future availability of the injectable macrolide antibiotic (erythromycin)...


    map background search result map search result map Data to Support Efficacy Studies of Injectable Tulathromycin for Reduction of Vertical Transmission of Renibacterium salmoninarum in Spring Chinook Salmon (Oncorhynchus tshawytscha) Data to Support Efficacy Studies of Injectable Tulathromycin for Reduction of Vertical Transmission of Renibacterium salmoninarum in Spring Chinook Salmon (Oncorhynchus tshawytscha)