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Fresh water is arguably the most valuable resource on the planet, but human activities threaten freshwater ecosystems. For example, use of synthetic chemicals, such as pesticides, road salts, and nutrients, has led to the ubiquitous contamination of aquatic systems, jeopardizing the integrity of ecological communities. Given the importance biodiversity plays in maintaining ecosystem health and function and the continued decline of freshwater species, it is vital to understand the direct, indirect, and lasting effects of synthetic contaminants on biota in freshwater systems. The majority of our knowledge regarding contaminant effects is comprised of short-term, single-contaminant laboratory toxicity tests that describe...