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We characterized a natural sea louse epizootic of Caligus clemensi and the effects of parasitism on Pacific herring Clupea pallasii in Port Angeles Harbor, WA, USA. Infestation prevalence on newly metamorphosed age0 Pacific herring reached 100% prevalence by mid-August. At this time, the mean louse intensity was 4.6 lice and a positive correlation occurred between louse intensity and Pacific herring body length. The epizootic then waned, with infestation prevalence decreasing to less than 25% and the mean parasite intensity falling below 1 louse by October. In controlled experiments, louse-induced mortality was negligible in controlled experiments. While skin injuries were not detected, motile lice preferentially...