This dissertation describes the modeling efforts on the Upper Mississippi River Basin (UMRB) using the Soil and Water Assessment Tool (SWAT) model. The main goal of this study is to apply the SWAT model to the UMRB to evaluate the model as a tool for agricultural policy analysis and climate change impact analysis. A sensitivity analysis using influence coefficient method was conducted for eight selected hydrologic input parameters to identify the most to the least sensitive parameters. Calibration and validation of SWAT were performed for the Maquoketa River Watershed for streamflow on annual and monthly basis. The model was then validated for the entire UMRB streamflow and evaluated for a climate change impact analysis. The results [...]